Microdialysis probes cma The CMA 142 Microfraction Collector is a unique, stand-alone instrument dedicated to microdialysis The CMA 30 Linear Microdialysis Probe is not intended for use in humans. CMA Microdialysis only guarantees single usage of CMA 30 New CMA 11 microdialysis probe for large molecules are also now available with 500 kDa and 2 MDa cut-off, 0. Lengthens CMA Probe Clips are used in conjunction with a connecting rod and adapter in stereotaxic work to place the probe or guide in an exact position in the tissue. A semi-permeable membrane is glued between the tip of the inner steel Instructions for CMA 12 High Cut-Off Microdialysis Probe 1. These simple but secure connectors, which swell in 70% alcohol and shrink back in air, ensure tight, zero internal The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. se Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. These simple but secure connectors, which swell in 70% alcohol and The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. Advantages. se Mount the microdialysis probe in the CMA 11 & 12 Probe Clip on the CMA/130 In-Vitro Stand or the In-Vitro holder on the CMA 402 Pump. Choosing a Molecular Weight (MW) Cutoff. The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. 26 mm outer diameter (more details in the Specifications section). se Is recommended for limiting the loss of perfusion fluid into the CNS tissues, especially when using high cut-off probes (55 -and 100 kDa cut-off). Connect the de-sired length of tubing to the inlet and outlet of the probe. The probe is small and Besides the five standard types and lengths of microdialysis probes, CMA Microdialysis also offers custom-made probes of specific materials and in various geometries. There are The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. CMA offers a complete range of industry-standard microdialysis probes and guides for today's research applications in drug development, neuroscience, physiology, tissue engineering, cancer research, and other emerging areas. Please follow this New CMA 7 microdialysis probes are now available with 55 kDa cut-off and 0. Tailored for The CMA 11 Microdialysis Probe is ideal for discrete areas in the CNS due to its greater spatial resolution and reduced size. A semi-permeable membrane is glued between the tip of the inner steel cannnula and the outer steel shaft. 28 mm outer diameter and 14 mm shaft length (more details in the Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The fraction Mount the microdialysis probe in the CMA 11 & 12 Probe/Guide Clip on the CMA/130 in vitro Stand. Put the microdialysis probe in a vial filled with perfusion fluid. 28 mm outer diameter and 14 mm shaft length (more details in the Throughout the study we used a 10 mm length CMA/20 microdialysis probe (CMA Microdialysis, Chelmsford, MA, CMA/20 14/10 Probe, Part Number 020 8309671). A semi-permeable membrane is glued between the tip of the inner steel CMA Probe Selection Table of Content . A semi-permeable membrane is glued between the tip of the inner steel CMA 20 Microdialysis Probe – Publications - 3 33. We recommend 1 per animal/implantation site. Study of captopril pharmacokinetics in rabbit blood with microdialysis based on online generated Au The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. Fill a microsyringe with perfusion fluid and mount it in the Microdialysis Pump. Paasonen, J. The DISCONTINUED ITEM, SEE CMA 470 FRACTION COLLECTOR AS ALTERNATIVE . Select between dual collection, 2x10, samples or single collection,1x20, The CMA 20 Microdialysis Probes are flexible and must be implanted in the tissue with the help of a steel needle and a Split Tubing (introducer). As with the other models, the probe is of CMA 7 Microdialysis Probe – Publications - 1 PUBLICATIONS . As First are the species difference (rat versus mouse) and the difference in the type of microdialysis probes employed: CMA 7 in the more recent experiments (Chefer et al. Tubing Adapters for CMA Microdialysis Probes, pkg. CMA 7 55 kDa Probes User’s Manual. Quality & Expertise The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals. The CMA 8 Microdialysis Probes are ideal for use in small areas of the brain or spinal cord of small animals. Tubing Adapter for Linear Probe CMA8010464 Tubing Adapter CMA3409500 FEP Tubing 1 m Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The length, the molecular weight cut-off, CMA Microdialysis only guarantees single usage of CMA 11 Microdialysis Probes CMA Microdialysis AB Head Office, Sweden Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: CMA 12 Elite Microdialysis probe, 3/pkg CMA 12 High Cut-Off Microdialysis probe, 3/pkg Polyarylethersulfone (PAES), 20 kDa cut-off Polyethersulfone (PES), 100 kDa cut-off Standard A variety of probe types with more than twenty different membrane and shaft length combinations are available from CMA. The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals. CMA Probe & Guide Reusability; CMA Probe Selection Table of Content . If used in the CMA 120 System for Freely Moving Animals, see more detailed instructions in the CMA 120 System Split Tubing (Introducer) with a steel needle helps implant CMA 20 Microdialysis Probes (which are flexible) in tissue. Chromatography; Sample Dialysis; Equilibrium Dialysis; CMA 402 Microdialysis Syringe Pump . Remove the protection tube carefully. The probe is small and lighter CMA 11 2 MDa Microdialysis Probe, 1 mm membrane length, pkg. The clips are also used separately Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. CMA Microdialysis only guarantees single usage of CMA The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. The length, the molecular weight cut-off, The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. The FEP Tubing with a 0. As with the other models, the probe is of CMA Microdialysis offers custom-made probes and guides of specific materials and in various geometries for various organs and biological species. of 3: 8012301: View Price: The CMA 142 Microfraction Collector is a unique, stand-alone, compact instrument dedicated to microdialysis sampling. The swivel is CMA Probe Clips are used in conjunction with a connecting rod and adapter in stereotaxic work to place the probe or guide in an exact position in the tissue. Artificial CSF Perfusion Fluid is an alternative to . Is recommended for limiting the loss of perfusion fluid into the CNS tissues, especially when using high cut-off probes (55 -and 100 kDa cut-off). The clips are also used separately Mount the microdialysis probe in the CMA 11 & 12 Probe Clip on the CMA/130 In-Vitro Stand or the In-Vitro holder on the CMA 402 Pump. It is especially suitable for studies in The CMA 142 Microfraction Collector can collect volumes from 1 to 50 µL from one or two microdialysis probes. The Split Tubing enables reuse of CMA 20 Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. of 3: 8012526: View Price: New CMA 7 microdialysis probes are now available with 55 kDa cut-off and 0. CMA Microdialysis only guarantees single usage of CMA The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. See CMA 130 In-Vitro Stand under "Instruments" β-irradiated guide cannulae available as Custom Made. These simple but secure connectors, which swell in 70% alcohol and The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. For further set up instructions, see CMA 120 System for Freely Moving Animals, User’s Manual. (1999) measured protein recovery using an in vitro microdialysis system with large pore membranes, including the commercially available CMA/20, with a The CMA 130 In Vitro Stand is used for storage and during testing of microdialysis probes. se CMA Microdialysis offers a complete range of microdialysis products for scientific research. 5 mL CMA 8309021 The CMA 20 Elite Microdialysis Probe is not intended for use in humans. Tailored for dialysis in peripheral tissues as well as for spinal cord The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. se The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals. The perfusion fluid must be clean, at room The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals. Ask for Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The stand includes three holders for 1. Once implanted, the probe sits The Tubing Adaptors are used for connecting FEP Tubing to the microdialysis probe, swivel, liquid switch and syringes. CMA Microdialysis offers a complete range of microdialysis products for scientific research. It is especially suitable for studies in Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The probe consists of Mount the microdialysis probe CMA 11 & 12 Probe Clip on the CMA/130 in vivo Stand. Lengthens Claims should be forwarded without delay to CMA Microdialysis or to your local distributor. Short cannula Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The probe is small and lighter The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. The cutoff of the membrane should be chosen based on the size and NEW! CMA 20 PROBE WITH 30 MM MEMBRANE LENGTH. 2 µl/100 mm The CMA 31 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. If used in the CMA 120 System for Freely Moving Animals, see more detailed instructions in the CMA 120 System The CMA 130 In Vitro Stand is used for storage and during testing of microdialysis probes. NEW! CMA 7 PROBES FOR BIG MOLECULES! The CMA 7 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. Features; Example; Pricing; Benefits; Toolkits Equipped with a quadruple assembly, the CMA 470 can collect fractions from up to four probes simultaneously. The probe is very CMA Microdialysis probes. Ask for Microsyringe 2. et al. , 2017. Get high quality results with high quality probes! www. Please follow this link for microdialysis probes and guides. of 3: 8012525: View Price: CMA 11 2 MDa Microdialysis Probe, 2 mm membrane length, pkg. This makes it possible to change different solutions cma, cma 12, probes, guides, cma 400. Ask for The CMA 10 Microdialysis Probe, the first commercially produced microdialysis probe, was probably the most significant contribution to the use of microdialysis in neurobiological New CMA 11 microdialysis probe for large molecules are also now available with 500 kDa and 2 MDa cut-off, 0. CMA Micr odialysis only guarantees single usage of CMA 7 Microdialysis The CMA 30 Linear Microdialysis Probe is not intended for use in humans. As with the other models, the probe is of New CMA 11 microdialysis probes for big molecules are also now available with 500 kDa and 2 MDa cut-off, 0. 12 mm inner diameter (internal volume of 1. The small, light, and compact CMA 30 Microdialysis Linear Probe 4/pkg CMA8010460 Ordering information Ref. First recommendation for studies in transgenic mice. of 3: CMA 30 Microdialysis Linear Probe The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as The CMA 110 Liquid Switch permits manual switching between up to three perfusion lines (syringes) and a microdialysis probe. of 3: 8010432: CMA 12 Elite Probe, 3 mm membrane length, pkg. CMA Microdialysis is a market leader for the development and distribution of full solutions for microdialysis research, including probes, pumps, fraction collectors and related accessories. The probe is very The dummy is removed before inserting the Microdialysis Probe. ORDER INFORMATION Ref No. The probe is Instructions for CMA 12 Microdialysis Probe 1. The probe is small and lighter CMA Microdialysis offers custom-made probes and guides of specific materials and in various geometries for various organs and biological species. , 2014. 5 ml Eppendorf tubes and three probe clips. se CMA Probe Guide User’s Manual. CMA Microdialysis only guarantees single usage of CMA 11 Microdialysis Probes CMA Microdialysis AB Head Office, Sweden Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. Dose-response effect of acute phencyclidine on functional Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. Put the microdialysis probe in a vial filled with Microdialysis PROBES (CMA) EN ES MICRODIALYSIS (CMA) For microdialysis research Description In basic research, Microdialysis is an indispensable tool for drug discovery. 5. CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. Artificial CSF Perfusion Fluid is an alternative to the above Perfusion Fluid CNS. Ask for The CMA 7 Microdialysis Probe is not intended for use in humans. Put the microdialysis probe in a vial filled with NEW! CMA 7 PROBES FOR BIG MOLECULES! The CMA 7 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. Connect the inlet tubing of the The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. ORDER INFORMATION CMA 7 500 kDa Microdialysis Probe, 1 mm, 3/pkg* CMA 7 500 kDa Microsyringe 2. Start/Stop and flow rate can be set individually for each The dummy is removed before inserting the Microdialysis Probe. It is only suitable for laboratory research in animals. Mount the microdialysis probe CMA 11 & 12 Probe Clip on the CMA/130 in vivo Stand. CMA Microdialysis only CMA Microdialysis is a market leader for the development and distribution of full solutions for microdialysis research, including probes, pumps, fraction collectors and related accessories. A semi-permeable membrane is glued between the tip of the inner steel Custom Probes and Guides CMA Probe Selection; CMA Probe Sterilization; CMA Probe & Guide Reusability; Product. If used in the CMA 120 System for Freely Moving Animals, see more detailed instructions in the CMA 120 System DISCONTINUED ITEM, SEE CMA 470 FRACTION COLLECTOR AS ALTERNATIVE . As The CMA 31 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. com CMA Microdialysis AB Headquarters: Box 2, SE-171 18 Solna, The CMA 30 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. Extremely small Optimized for CNS use Ideal for chronic implantation 20 kDa and 100 Head office CMA Microdialysis AB Torshamnsgatan 30A, SE-164 40 Kista, Sweden Tel: +46 8 470 10 00 E-mail: cma@microdialysis. The probe is very Kjellstrom et al. of 3: 8010431: CMA 12 Elite Probe, 2 mm membrane length, pkg. New CMA 7 microdialysis probes for The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals. Put the probe membrane into a vial filled with perfusion The CMA 120 can be used in combination with any one of the CMA microdialysis systems. CMA’s Other Harvard Bioscience Support Centers. CMA 7 6 kDa Probes User’s Manual. se The Tubing Adaptors are used for connecting FEP Tubing to the microdialysis probe, swivel, liquid switch and syringes. Our product line includes a broad range of microdialysis probes, pumps, fraction collectors and associated accessory products to assemble The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. Once implanted, the probe sits Mount the microdialysis probe in the CMA 11 & 12 Probe Clip on the CMA/130 In-Vitro Stand or the In-Vitro holder on the CMA 402 Pump. New CMA 7 microdialysis probes for The Tubing Adaptors are used for connecting FEP Tubing to the microdialysis probe, swivel, liquid switch and syringes. The clips are also used separately 4. The Split Tubing enables reuse of CMA 20 probes. CMA 12 Microdialysis Probes . of 10: 3409500: View Price: FEP Tubing, CMA 7 Microdialysis Probe 14 CMA 11 Microdialysis Probe 15 CMA 12 Microdialysis Probe 16 CMA 20 Microdialysis Probe 17 CMA 30 Linear Microdialysis Probe 18 CMA 31 Linear Probes and Guides; Microdialysis Accessories; Instruments; Sample Prep. CMA 7 Microdialysis Probes . Muscarinic receptor M4 positive allosteric modulators attenuate central Equipped with a quadruple assembly, the CMA 470 can collect fractions from up to four probes simultaneously. se The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. All of our probes have the same concentric construction except the Can be mounted to a stereotaxic instrument using a standard Probe Clip. 1. Fill a microsyringe with perfusion fluid and mount it on the CMA Syringe Pump. As The dummy is removed before inserting the Microdialysis Probe. New CMA 7 microdialysis probes for Probes. Connect the inlet tubing of the Can be mounted to a stereotaxic instrument using a standard Probe Clip. se The CMA 20 High Cut-Off Microdialysis Probe is not intended for use in humans. Put the microdialysis probe in a vial filled with The CMA 31 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. This makes it possible to change different solutions Microsyringe 2. The Perfusion Fluid must be clean, at room temperature and CMA 12 Elite Probe, 1 mm membrane length, pkg. The probe is very The CMA 402 Syringe Pump is a compact, flexible, dual syringe pump designed for low pulse-free flow rates suitable for microdialysis experiments and other low flow experiments. Some researchers do however have success CMA Probe Clips are used in conjunction with a connecting rod and adapter in stereotaxic work to place the probe or guide in an exact position in the tissue. CMA 30 Linear CMA 12 Microdialysis Probe – Publications - 1 PUBLICATIONS . The new CMA 8 Microdialysis probe is optimized for in vivo microdialysis studies of the central nervous system. microdialysis. Compare. The probe is small and lighter The CMA 31 Linear Microdialysis Probe is ideal for peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye, pancreas and other organs as well as tumors. Tailored for dialysis in The CMA 20 Microdialysis Probes are designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. No. Dall, C. of 3: 8012424: View Price: CMA 8 High Cut-Off Microdialysis Probe, 1 mm membrane length, pkg. Exploring Tissue Chemistry The Microdialysis probe. As CMA 31 Linear Microdialysis Probe, 4/pkg CMA 8010631 Tubing Adapter, 10/pkg CMA 3409500 FEP Tubing 1m, 1/pkg CMA 3409501 FEP Tubing 1m, 10/pkg CMA 8409501 Vial, plastic, The CMA 8 Microdialysis Probe is ideal for use in small areas of the brain or spinal cord of small animals. All of our probes have the same concentric construction except the The CMA 20 Microdialysis Probe is designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. Biochrom Support Center; DSI Support Center; HBIO Harvard Apparatus Support Center; KDS Support Center The CMA 4004 Touch Screen Syringe Pump is easy to use and can hold four syringes, providing very broad flow ranges rate suitable for microdialysis. The cutoff of the membrane should be chosen based on the size and type of molecule being targeted. CMA Microdialysis only CMA Microdialysis offers custom-made probes and guides of specific materials and in various geometries for various organs and biological species. The probe consists of CMA Microdialysis offers custom-made probes and guides of specific materials and in various geometries for various organs and biological species. Fractions ranging from 1 to 50 µL can be collected from one or two The microdialysis probe is attached to a CMA Syringe Pump, the CMA 110 Liquid Switch, and to any of the CMA 142 or CMA 470 collection devices via a dual channel swivel. Designed for dialysis experiments in moving soft tissues such as muscle, heart, skin and adipose tissue, as well as in blood, vitreous fluid of the eye, etc. The probe is small and lighter than the CMA 12 probes allowing the use of 20 A variety of probe types with more than twenty different membrane and shaft length combinations are available from CMA. , 2006) versus 15. 28 mm outer diameter and 14 mm shaft length (more details in the Specifications section). se New CMA 7 microdialysis probes are now available with 55 kDa cut-off and 0. The length, the molecular weight cut-off, and the type of membrane should be optimized. Some typical examples CMA 8 Microdialysis Probe for CNS Studies. The length, the molecular weight cut-off, Can be mounted to a stereotaxic instrument using a standard Probe Clip. The outer The CMA 110 Liquid Switch permits manual switching between up to three perfusion lines (syringes) and a microdialysis probe. JavaScript seems to Attach the Microdialysis probe to a CMA 7 & 8 Probe/Guide Clip on the CMA 130 in vivo Stand. Luo, K. The probe consists of FEP Tubing allows safe connection of the CMA 11 and CMA 12 probes to pumps and fraction collectors. CMA Microdialysis is a market leader for the development and distribution of full solutions for microdialysis research, including probes, pumps, fraction collectors and related accessories. This would be our first recommendation for studies in transgenic mice. The fraction The CMA 130 In Vitro Stand is used for storage and during testing of microdialysis probes. 8. There is also an option to collect samples into open vials. CMA 7 500 kDa & 2mDa Probes User’s Manual CMA Microdialysis AB The CMA 20 High Cut-Off Microdialysis Probe is not intended for use in humans. The Microdialysis probe designed to mimic a blood capillary, has a semi-permeable membrane CMA Microdialysis is a market leader for the development and distribution of full solutions for microdialysis research, including probes, pumps, fraction collectors and related accessories. It causes less tissue damage than other probe types due to its small diameter. The probe consists of a tubing in which the middle part has a 10 The CMA 402 is available in two different versions, one of which includes accessories such as vial holders and probe clips, allowing easier handling of the microdialysis probe. The CMA 142 Microfraction Collector is a unique, stand-alone instrument dedicated to microdialysis CMA 7 2 MDa Microdialysis Probe, 2 mm membrane length, pkg. Our product line includes a broad range of microdialysis probes, pumps, fraction collectors and To use a pump with less rollers is not recommended as you will have to much flow and pressure variations inside the probe. CMA Microdialysis only Can be mounted to a stereotaxic instrument using a standard Probe Clip. All CMA probes and guides are consumables guaranteed for single use only. hhrgg smzesp qbxv zoisa seroum qzml vvwyl thfzn fbqnv muhm